127 TREATMENT OF CHRONIC TYPE B HEPATITIS WITH RECOMBINANT ALPHA 2a INTERFERON IN HBeAg POSITIVE CHILDREN

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Comparison of lamivudine and alpha-interferon combination with alpha-interferon alone in the treatment of HBeAg-positive chronic hepatitis B.

AIM To compare the efficacy of a combination of a-interferon (IFN-a) and lamivudine with IFN-a alone in the treatment of patients with HBeAg-positive chronic hepatitis B (CHB). METHODS Sixty-eight treatment-naove patients with HBeAg-positive CHB were randomized to receive either 9 MU of IFN-a2a three times a week and lamivudine 100 mg daily (Group 1), or IFN-a2a alone in the same dosage (Grou...

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efficacy of pegylated interferon in treatment-experienced chinese patients with hbeag positive chronic hepatitis b

background after treatment cessation, a high prevalence of relapse was reported in chronic hepatitis b (chb) patients in china, especially in nucleot(s)ide analogues (nucs)-experienced patients. re-treatment for these patients remains unsolved. objectives this study aims to evaluate the efficacy of pegylated interferon in hbeag positive patients with exposure to antiviral therapy. patients and ...

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Pegylated Interferon Alfa in HBeAg-positive Chronic Hepatitis B

Background: Treatment with interferon-alfa has been shown to be effective in one-third of hepatitis B e antigen-positive chronic hepatitis B patients, but is clinically associated with relevant adverse events. Aim: To investigate the safety of peginterferon alfa-2b in 300 hepatitis B e antigen-positive patients with compensated liver disease. Methods: Patients were treated with peginterferon al...

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Efficacy of PEGylated Interferon in Treatment-Experienced Chinese Patients With HBeAg Positive Chronic Hepatitis B

BACKGROUND After treatment cessation, a high prevalence of relapse was reported in chronic hepatitis B (CHB) patients in China, especially in nucleot(s)ide analogues (NUCs)-experienced patients. Re-treatment for these patients remains unsolved. OBJECTIVES This study aims to evaluate the efficacy of PEGylated interferon in HBeAg positive patients with exposure to antiviral therapy. PATIENTS ...

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Treatment of chronic hepatitis C with recombinant interferon alpha 2b.

The authors studied 70 patients affected by chronic hepatitis C where diagnosis had been made by clinical and histological tests. Intramuscular recombinant alpha 2b interferon (3 x 10(6)) was administered to 35 patients every second evening for 6 months, whereas the other 35 received aspecific treatment. Our results revealed normalization of transaminase in 57% of the patients, with distinct im...

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ژورنال

عنوان ژورنال: Pediatric Research

سال: 1990

ISSN: 0031-3998,1530-0447

DOI: 10.1203/00006450-199009000-00151